About ratiochem

... is a young, dynamic company based in Bavaria/Germany
... offers broad range of

- fine chemicals
- intermediates
- APIs
- metals
- custom manufacturing
- sourcing

... provides consulting as well as analytical services
... is committed to deliver safely and on time top-quality products at low prices
... supports the customer by lowering manufacturing costs
... arranges custom manufacturing of desired chemical compounds at low costs
... with respect to this also offers the corresponding consulting and analytical services to the costumer
  (e.g., GMP implementation, patent affairs ...)


About the founder of ratiochem

Dr. Lothar Fröhlich - Geschäftsführer ratiochem GmbH

Dr. Dipl. Chem. Lothar Fröhlich
Managing Director ratiochem GmbH

Dr. Fröhlich received his Diploma in synthetic organic chemistry and the Ph.D. degree in pharmacology/biochemistry from the University of Würzburg, Germany.
He has held various positions as Scientist in R&D and Leadership Positions in industries dealing with manufacturing of compounds for application in chemical and pharmaceutical companies.
He is the author or coauthor of  numerous scientific papers and the holder of patents in these fields.
He received several scientific awards for these works.

In 2006 he has founded the ratiochem GmbH.



[1] Adam, W.; Fröhlich, L.; Nau, W. M.; Wirz, J. Effects of Symmetrical Diaryl Substitution on Intersystem Crossing in 1,3-Cyclopentanediyl Triplet Biradicals. J. Am. Chem. Soc. 1993, 115, 9824-9825.
[2] Adam, W.; Fröhlich, L.; Nau, W. M.; Korth, H. G.; Sustmann, R. Substituenteneinflüsse auf die Nullfeldparameter von lokalisierten Triplett-1,3-Cyclopentandiyl-Diradikalen. Angew. Chem. 1993, 105, 1383-1384.
[3] Linker, T.; Fröhlich, L. Regio- und diastereoselektive Photooxygenierung chiraler 2,5-Cyclohexadien-1-carbonsäuren. Angew. Chem. 1994, 106, 2064-2066.
[4] Linker, T.; Fröhlich, L. Substituent Effects in the Highly Regioselective and Diastereoselective Ene Reaction of Singlet Oxygen with Chiral Cyclohexadienes. J. Am. Chem. Soc. 1995, 117, 2694-2697.
[5] Peters, K.; Peters, E. M.; Linker, T.; Fröhlich, L. Crystal structure of 1-hydroperoxy-3-isopropyl-2-methylenecyclohex-4-ene-3-carboxylic acid, C11H16O4. Zeitschrift für Kristallographie 1996, 211, 359.
[6] Peters, K.; Peters, E. M.; Linker, T.; Fröhlich, L. Crystal structure of 1,2-dimethyl-2,5-cyclohexadiene-1-carboxylic acid, C9H12O2. Zeitschrift für Kristallographie 1996, 211, 361.
[7] Bömmel, H. M.; Reif, A.; Fröhlich, L. G.; Frey, A.; Hofmann, H.; Marecak, D. M.; Groehn, V.; Kotsonis, P.; La, M.; Köster, S.; Meinecke, M.; Bernhardt, M.; Weeger, M.; Ghisla, S.; Prestwich, G. D.; Pfleiderer, W.; Schmidt, H. H. H. W. Anti-pterins as Tools to Characterize the Function of Tetrahydrobiopterin in NO Synthase. J. Biol. Chem. 1998, 273, 33142-33149.
[8] Kotsonis, P.; Frey, A.; Fröhlich, L. G.; Hofmann, H.; Reif, A.; Wink, D. A.; Feelisch, M.; Schmidt, H. H. H. W. Autoinhibition of Nitric Oxide Synthase – Distinct Effects of Reactive Nitrogen and Oxygen Species on Enzyme Activity and Quatenary Structure. Biochem. J. 1999, 340, 745-752.
[9] Reif, A.; Fröhlich, L. G.; Kotsonis, P.; Frey, A.; Bömmel, H. M.; Wink, D. A.; Pfleiderer, W.; Schmidt, H. H. H. W. Tetrahydrobiopterin Inhibits Monomerization and is Consumed During Catalysis in Neuronal NO Synthase. J. Biol. Chem. 1999, 274, 24921-24929.
[10] Fröhlich, L. G.; Kotsonis, P.; Traub, H.; Taghavi-Moghadam, S.; Al-Masoudi, N.; Hofmann, H.; Strobel, H.; Matter, H.; Pfleiderer, W.; Schmidt, H. H. H. W. Inhibition of Neuronal Nitric Oxide Synthase by 4-Amino Pteridine Derivatives: Structure-Activity Relationship of Antagonists of (6R)-5,6,7,8-Tetrahydrobiopterin Cofactor. J. Med. Chem. 1999, 42, 4108-4121.
[11] Butt, E.; Bernhardt, M.; Smolenski, A.; Kotsonis, P.; Fröhlich, L. G.; Sickmann, A.; Meyer, H. E.; Lohmann, S. M.; Schmidt, H. H. H. W. Endothelial Nitric Oxide Synthase (Type III) is Activated and Becomes Calcium-Independent upon Phosphorylation by Cyclic Nucleotide-dependent Protein Kinases. J. Biol. Chem. 2000, 275, 5179-5187.
[12] Kotsonis, P.; Fröhlich, L. G.; Shutenko, Z. V.; Horejsi, R.; Pfleiderer, W.; Schmidt, H. H. H. W. Allosteric Regulation of Neuronal Nitric-Oxide Synthase by Tetrahydrobiopterin and Suppression of Auto-damaging Superoxide. Biochem. J. 2000, 346, 767-776.
[13] Groehn, V.; Fröhlich, L., Schmidt, H. H. H. W.; Pfleiderer, W. Pteridine-Based Photoaffinity Probes for Nitric Oxide Synthase and Aromatic Amino Acid Hydroxylases. Helv. Chim. Acta 2000, 83, No. 10, 2738-2750.
[14] Kotsonis, P.; Fröhlich, L. G.; Raman, C. S.; Li, H.; Berg, M.; Gerwig, R.; Groehn, V.; Kang, Y.; Al-Masoudi, N.; Taghavi-Moghadam, S.; Mohr, D.; Münch, U.; Schnabel, J.; Martasek, P.; Masters, B. S. S.; Strobel, H.; Poulos, T.; Matter, H.; Pfleiderer, W. and Schmidt, H. H. H. W. Structural basis for Pterin antagonism in nitric oxide synthase: Development of novel 4-Oxo Pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin. J. Biol. Chem. 2001, 276, 49133-49141.
[15] Houbertz, R.; Fröhlich, L.; Schulz, J.; Popall, M. Inorganic-organic Hybrid Materials (ORMOCERÒs) for Multilayer Technology – Passivation and Dielectric Behavior. Mat. Res. Soc. Symp. Proc. 2001, Vol. 665, 321-326.
[16] Matter, H.; Kotsonis, P.; Klingler, O.; Strobel, H.; Fröhlich, L. G.; Frey, A.; Pfleiderer, W.; Schmidt, H. H. H. W. Structural Requirements for Inhibition of the Neuronal Nitric Oxide Synthase (NOS-I): 3D-QSAR Analysis of 4-Oxo and 4-Amino-Pteridine-Based Inhibitors. J. Med. Chem. 2002, 45, 2923-2941.
[17] Fröhlich, L.; Houbertz, R.; Jacob, S.; Popall, M.; Müller-Fiedler, R.; Graf, J.; Munk, M.; von Zychlinski, H. Inorganic-Organic Hybrid Polymers as Photo-Patternable Dielectrics for Multilayer Microwave Circuits. Mat. Res. Soc. Symp. Proc. 2002, Vol. 726, 349-354.
[18] Streppel, U.; Dannberg, P.; Wächter, C.; Bräuer, A.; Fröhlich, L.; Houbertz, R.; Popall, M. New wafer-scale fabrication method for stacked optical waveguide interconnects and 3 D micro-optic structures using photoresponsive (inorganic-organic hybrid-) polymers. Opt. Mat. 2002, 21/1-3, 479-487.
[19] Serbin, J.; Egbert, A.; Ostendorf, B.; Chichkov, B. N.; Houbertz, R.; Domann, G.; Schulz, J.; Cronauer, C.; Fröhlich, L.; Popall, M. Femtosecond laser-induced two-photon polymerization of inorganic organic hybrid materials  for applications in photonics. Opt. Lett. 2003, 28/5, 301-303.
[20] Johansson, C.; Uhlig, S.; Tageman, O.; Alping, A.; Haglund, J.; Robertsson, M.; Popall, M.; Fröhlich, L. Microwave Circuits in Multilayer Inorganic-Organic Polymer Thin Film Technology on Laminate Substrates. IEEE Transactions on Advanced Packaging, 2003, Vol. 26, 81-89.
[21] Houbertz, R.; Schulz, J.; Fröhlich, L.; Domann, G.; Popall, M. Inorganic-organic hybrid materials for polymer electronic applications. Mat. Res. Soc. Symp. Proc. 2003, Vol. 769, 239-244.
[22] Houbertz, R.; Schulz, J.; Fröhlich, L.; Domann, G.; Popall, M. Inorganic-organic hybrid materials for real 3-D sub-µm lithography. Mat. Res. Soc. Symp. Proc. 2003, Vol. 780, 175-180.
[23] Houbertz, R.; Domann, G.; Cronauer, C.; Schmitt, A.; Martin, H.; Park, J.-U.; Fröhlich, L.; Buestrich, R.; Popall, M.; Streppel, U.; Dannberg, P.; Wächter, C.; Bräuer, A. Inorganic-organic hybrid materials for application in optical devices. Thin Solid Films, 2003, 442, 194-200.
[24] Houbertz, R.; Fröhlich, L.; Popall, M.; Streppel, U.; Dannberg, P.; Bräuer, A.; Serbin, J.; Chichkov, B. Inorganic-Organic Hybrid Polymers for Information Technology: from Planar Technology to 3D Nanostructures. Advanced Engineering Materials, 2003, 5 No. 8, 551-555.
[25] Fröhlich, L.; Linker, T. Simple and Diastereoselective Synthesis of an A-Ring Precursor of Dihydroxyvitamin D3 (Calcitriol) by Photooxygenation. Synlett, 2004, 15, 2725-2727.
[26] Houbertz, R.; Domann, G.; Schulz, J.; Olsowski, B.; Fröhlich, L.; Kim, W.S. Impact of photoinitiators on the polymerization and the optical properties of inorganic-organic hybrid polymers. Applied Physics Letters, 2004, 84/7, 1105-1107.
[27] Matter, H.; Kumar, H. S. A.; Federov, R.; Frey, A.; Kotsonis, P.; Hartmann, E.; Fröhlich, L. G.; Reif, A.; Pfleiderer, W.; Scheurer, P.; Ghosh, D. K.; Schlichting, I.; Schmidt, H. H. H. W. Structural Analysis of Isoform-Specific Inhibitors Targeting the Tetrahydrobiopterin Binding Site of Human Nitric Oxide Synthases. J. Med. Chem., 2005, 48, 4783-4792.
[28] Uhlig, S.; Domann, G.; Houbertz, R.; Fröhlich, L.; Schröder, H.; Krissler, J.;  Lang, G.; Robertsson, M. Preventing of dewetting effects for inorganic-organic hybrid polymers applied in sequentially buildup (SBU) technology without surface pretreatments. IEEE Transactions on Electronics Packaging Manufacturing, 2006, 297-307.
[29] Uhlig, S.; Fröhlich, L.; Chen, M.; Arndt-Staufenbiel, N.; Schröder, H.; Houbertz, R.; Popall, M.; Robertsson, M. Polymer optical interconnects – a scalable large-area panel processing approach. IEEE Transactions on Advanced Packaging, 2006, 29/1, 158-170.



[1] Pfleiderer, W.; Schmidt, H.; Fröhlich, L.; Kotsonis, P.; Taghavi-Moghadam, S.
N-substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent.
DE 199 44 767 A1, WO 01/21619 A1.
[2] Houbertz, R.; Schulz, J.; Fröhlich, L.; Popall, M.; Chichkov, B.; Serbin, J. Verfahren zur Erzeugung dreidimensionaler Körper oder Oberflächen/Oberflächenkomponenten aus organopolysiloxanhaltigen Ausgangsmaterialien durch Laser-Bestrahlung. DE 101 52 878 A1, EP 1 499 490, WO 03/037606 A1.
[3] Fröhlich, L.; Jacob, S.; Popall, M.; Houbertz, R. Photochemisch und/oder thermisch strukturierbare Harze auf Silanbasis, einstufiges Verfahren zu deren Herstellung, dabei einsetzbare Ausgangsverbindungen und Herstellungsverfahren für diese. DE 101 48 894 A1, EP 1 453 886 A1, US 2004/242830 A1, WO 03/031499 A2.
[4] Jacob, S.; Fröhlich, L.; Olma, K.; Popall, M.; Kahlenberg, F. Protonenleitfähige Membranen/Schichten und Verfahren zu deren Herstellung. DE 101 63 518 A1, EP 1 323 767 A2, US 2003/0144450 A1.
[5] Jacob, S.; Popall, M.; Fröhlich, L.; Kahlenberg, F.; Olma, K. Verfahren zur Herstellung von Styryl-funktionalisierten Alkoxysilanen. DE 101 59 859 C1, EP 1 318 153 B1, US 2003/0139621 A1.
[6] Kondo, N.; Hayashi, T.; Popall, M.; Fröhlich, L.; Houbertz, R.; Cochet, S. Condensation Products of Silicic Acid Derivatives and Optical Waveguide Devices Using the Same. WO 07/088640 A1.


Academic Awards

[1] Phoenix Pharmacy Science Prize 2000 for Pharmacology.
[2] Prize for PhD Thesis from the Faculty of Chemistry and Pharmacy at the University of Würzburg in the Year 2001.
[3] „Wissenschaftspreis des Stifterverbandes für die Deutsche Wissenschaft im Jahr 2002.“